Autism and NIDS - Controlling Candida and Yeast
While taking the risk of opening a medical controversy, this author certainly believes there is a logical connection between yeast and a dysfunctional immune system. However, this theory is not yet widely accepted by the medical community, but over the last few years has become easier to talk about and “discuss”. Candida is a yeast-like fungus that is present in all our bodies. Presumably, yeast / Candida is in every normal G.I. tract. That is where the confusion begins.
Normally, a healthy immune system keeps the yeast in check. If the immune system is not working properly, the yeast have a chance to overgrow and become a problem. Yeast is one of the likely pathogens contributing to a metabolic imbalance that is a secondary result of a dysfunctional / dysregulated immune system. It is NOT the primary reason or cause for autism.
There is logic in saying that if an immune system is dysregulated, a secondary problem potentially due to Candida needs to be treated. Some doctors hypothesize that autism is caused by a “leaky gut.” With this theory comes the assumptions that withdrawing allergens and treating a yeast overgrowth, will help the GI tract to return toward normal. The problem with this thinking is that if yeast is not the cause of autism or PDD, then treating Candida is not going to end the autistic or PDD state. I believe it is only one of the many steps needed to help normalize the body.
Many children afflicted with autism have had frequent ear infections as young children and have taken excessive amounts of antibiotics. This has exasperated the yeast problem in these children. Other possible contributors to Candida overgrowth are hormonal treatments (i.e. steroids, BCP pills, ?? secondary exposure), immunosuppresant drug therapy, exposure to herpes, chicken pox, or other “chronic” viruses, or exposure to chemicals that might upset the immune system. There is an increased probability, that a “general” environmental factor affecting our immune systems (i.e. ozone layer depletion, “toxic” chemicals, etc.) may be operative, affecting many children and adults.
Because it is impossible and not practical to expect anyone to stay on a totally yeast-free diet, ongoing medication, anti-fungal supplements, and avoidance of dietary negatives are necessary to control Candida. Even with the use of anti-fungal drugs, it is still important to limit sugar when there is a yeast problem, because yeast grows 200 times faster in the presence of sugar.
If a potent anti-fungal such as Diflucan or Nizoral is used, it can be assumed that within 1 - 2 months most all of the yeast will die off. I do not use Nilstat or Nystatin. For most children Nystatin is ineffective. And yeast, like bacteria with antibiotics, have become resistant to Nilstat (and other antifungals).
Usually, I will use Nizoral or Diflucan for about four to six months while trying to alleviate other stresses on the immune system and “maximize” a child’s function. In 7- 12 days some patients experience “die off.” This is the only time, a “negative” reaction to a medication can be a good sign.
When the yeast is being killed one experiences either a “sensitization” reaction to “products” of the yeast being killed, or there is release of “formaldehyde” like products or other potentially toxic derivatives, that can contribute to negative symptoms in a patient, including bouncing off the walls, miserable, and irritated. I know it is ironic, because it actually is a good sign that the child has a yeast problem that can be corrected with medication.
It is important that the parents check in during “die-off” so I can be sure what is occurring is indeed die-off and not a reaction to the medication. Die-off usually lasts about 7-14 days and after that time the change in the child can be rather dramatic. If the die-off does not end in 14 - 17 days, it is generally a reason to change choice of anti-fungal.
If the treatment is successful, usually eye-contact improves. The children seem more tuned in and less “foggy.” Parents report that after the yeast is under control the frequency of inappropriate noises, teeth grinding, biting, hitting, hyperness, and aggressive behavior decrease. The children no longer act almost drunk by being silly and laughing inappropriately.
While on Nizoral or Diflucan, I have the patient take monthly blood tests to monitor liver function before any damage might occur. I tend to be on the cautious side, “officially” testing is recommended every 2 - 3 months.
I change medication at six months, though in theory one could go longer. The reason I stop at six months is because Nizoral has a very mild effect on the adrenocortical axis. It’s part of the internal steroid mechanism. While this may even be part of how “Nizoral” helps the body, it also limits how long one should be on Nizoral. Generally, I will try to switch to Amphotericin B, which has recently been licensed as an oral liquid in this country, can now be legally compounded by certain pharmacies in the U.S.
If the antifungal therapy is stopped completely, and the body’s immune system has not returned to normal, the yeast will return. Ultimately, the key is the body’s own ability to keep in check an organism that it doesn’t want to have there to start with.
Some doctors mistakenly give medication to control the yeast for only a few weeks or even a month. Then the treatment is stopped because the child is doing better. The problem with this kind of therapy is that if a child is helped for a short time and then the treatment is withdrawn, the yeast is going to come back, perhaps even as a stronger, more resistant strain. Whereas if the treatment took that child to normal, and their immune system became normal, it would be possible to withdraw all treatment and the child would remain healthy.
Michael J. Goldberg M.D., F.A.A.P.
Avalar Medical Group, Inc.
5620 Wilbur Avenue, Suite 318
Tarzana, Claifornia 91356
Telephone (818) 343-1010
Fax (818) 343-6585
Pediatrics & Young Adults
ADHD/ADD-Learning Disabilities,
Immune Dysfunction Autism
Source: General
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